Corrigendum

Abstract

Figure 1. Illustrative scheme of naive T cell differentiation into T helper type 1 (Th1), Th2, Th17 or regulatory T (Treg) cells, depending on the cytokine profile. Interleukin-12 (IL-12) and interferon-c (IFN-c) stimulated naive T cells differentiate to Th1 cells. These cells express IFN-c and tumour necrosis factor-a (TNF-a), and are responsible for intracellular parasite clearance. IL-4 stimulated naive T cells induce a Th2 response. Th2 cells express IL-4, IL-5 and IL-13, and are responsible for clearance of extracellular parasites. Transforming growth factor-b (TGF-b) stimulated naive T cells induce a Treg response. Treg cells express TGF-b and IL-10 and are responsible for tolerance and pregnancy success. These three cell types express one cytokine responsible for its induction, in a positive feedback mechanism. TGF-b and IL-6 stimulated naive T cells induce a Th17 response. Th17 cells express IL-17, IL-21 and IL-22 and are responsible for autoimmunity and pregnancy loss. Th17 cells do not present a positive feedback mechanism, but IFN-c or IL-4 can inhibit the differentiation from naive T cells to Th17. Moreover, IL-6 and IL-12 inhibit Treg and Th2 cells, respectively.