Surgical treatment of peri-implantitis with or without a deproteinized bovine bone mineral and a native bilayer collagen membrane. A randomized clinical trial.

Abstract

AIM\nTo assess whether the use of deproteinized bovine bone mineral (DBBM) and native bilayer collagen membrane (NBCM) improved healing of peri-implantitis-related bone defects at 12 months.\n\n\nMATERIALS AND METHODS\nIn a multicentre randomized clinical trial, 32 individuals received surgical debridement (CG), and 34 adjunct use of DBBM and NBCM (TG). Radiographic defect fill (RDF), probing pocket depth (PPD), bleeding on probing (BOP) suppuration (SUP), recession (REC), cytokines (IL-1β, IL-1ra, IL-6, IL-8, IL-12, IP10, PDGF-BB, TNF-α, VEGF), and patient-reported outcomes (PROs) were evaluated at 3, 6, 9 and 12 months.\n\n\nRESULTS\nRDF at deepest site amounted 2.7 ±\u20091.3\u2009mm in TG and 1.4 ±\u20091.2\u2009mm in CG (p <\u20090.0001). PPD was reduced by 1.9\u2009mm in TG and 2.3\u2009mm in CG (p =0.5783). There were no significant differences between groups regarding reductions of BOP, SUP, REC, cytokines levels, or OHIP 14 scores at 12 months. Successful treatment (RDF ≥1.0\u2009mm, PPD ≤5\u2009mm, ≤1/4 site with BOP grade 1, no SUP) were identified in 32% in TG and 21 % in CG.\n\n\nCONCLUSIONS\nDBBM and NBCM resulted in significantly more RDF than debridement alone. No difference was found in any clinical parameters or PROs between groups.