Mechanism and clinical applications of needle-free injectors in dermatology: Literature review.

Abstract

BACKGROUND\nNeedle-free jet injectors are devices that deliver drugs using a high-speed jet without a needle. Recent studies have significantly increased our understanding of the mechanisms of needle-free jet injectors, and technical advancements have broadened the scope of application of the device.\n\n\nOBJECTIVES\nWe aimed to provide an up-to-date review of previous literature regarding the mechanism of action and clinical applications of needle-free jet injectors in dermatology field.\n\n\nMETHODS\nWe conducted a PUBMED search for studies on needle-free jet injectors using using the following parameters: Pneumatic injector OR needleless injector OR needle-free injector OR jet injector. Among 191 results, 72 articles focusing on their mechanisms of action, cutaneous delivery patterns, and clinical applications in dermatology were selected for review.\n\n\nRESULTS\nSignificant clinical evidence has been published confirming the potential of needle-free jet injectors in treating various dermatologic conditions. In particular, these devices have the potential to be used in various skin remodeling treatment, especially in skin rejuvenation procedures by injecting various aesthetic materials.\n\n\nCONCLUSION\nAs proven by accumulated experience, the applications of NFJIs are not restricted to vaccine or insulin delivery in dermatology field. However, this literature review shows that until now, there are no clinical guidelines that standardize the optimal parameters when using NFJIs on various clinical settings. Therefore, further studies should be performed in order to investigate the full potential of these devices in dermatology, to ensure safe and effective outcomes in clinical practice.