Thrombin generation measured by two platforms in patients with a bleeding tendency: Reply

Abstract

T WIT TER Will Thomas @willtho76313310 R E FE R E N C E S 1. Cornette M, Monteyne T, De Kesel PM, Devreese KMJ. Thrombin generation measured by two platforms in patients with a bleeding tendency. J Thromb Haemost. 2021;19:14601471. 2. Thomas W, Downes K, Desborough MJR. Bleeding of unknown cause and unclassified bleeding disorders; diagnosis, pathophysiology and management. Haemophilia. 2020;26:946957. 3. Ay C, Haselbock J, Laczkovics C, Koder S, Pabinger I. Thrombin generation in patients with a bleeding tendency of unknown origin. Ann Hematol. 2011;90:10991104. 4. Holm E, Zetterberg E, Lövdahl S, Berntrop E. Patients referred for bleeding symptoms of unknown cause: does evaluation of thrombin generation contribute to diagnosis? Mediterr J Hematol Infect Dis. 2016;8:e2016014. 5. Hofer S, Ay C, Rejtö J, et al. Thrombingenerating potential, plasma clot formation, and clot lysis are impaired in patients with bleeding of unknown cause. J Thromb Haemost. 2019;17:14781488. 6. Alves GS, Orsi FA, SantiagoBassora FD, et al. Laboratory evaluation of patients with undiagnosed bleeding disorders. Blood Coagul Fibrinolysis. 2016;27:500505. 7. MacDonald S, Wright A, Beuche F, et al. Characterization of a large cohort of patients with unclassified bleeding disorder; clinical features, management of haemostatic challenges and use of global haemostatic assessment with proposed recommendations for diagnosis and treatment. Int J Lab Hematol. 2020;42:116125. 8. Veen CSB, Huisman EJ, Cnossen MH, et al. Evaluation of thromboelastometry, thrombin generation and plasma clot lysis time in patients with bleeding of unknown cause: a prospective cohort study. Haemophilia. 2020;26:e106e115. 9. Obaji SG, Slatter DA, Tyyrell VJ, Jenkins PV, O’Donnell VB, Collins PW. Uncharacterised bleeding disorders are associated with reduced platelet and microparticle thrombin generation and decreased procoagulant oxidised phosphatidylcholine. Haemophilia. 2020;26(S2):27181. 10. Mehic D, Colling M, Pabinger I, Gebhart J. Natural anticoagulants: a missing link in mild to moderate bleeding tendencies. Haemophilia. 2021. doi: 10.1111/hae.14356. Epub ahead of print.