The efficacy and safety of mirabegron in treating ureteral stent-related symptoms: A systematic review and meta-analysis.

Abstract

OBJECTIVES\nThis meta-analysis aimed to assess the efficacy and safety of mirabegron in treating ureteral stent-related symptoms.\n\n\nMETHODS\nMEDLINE, EMBASE, and the Cochrane Controlled Trials Register were searched to identify randomized controlled trials (RCT) of mirabegron in treating ureteral stent-related symptoms. We conducted a systematic review and meta-analysis based on the eligible RCT.\n\n\nRESULTS\nFive RCT including 546 patients and comparing mirabegron with placebo or blank control were involved in the present research. Regarding efficacy, mirabegron was superior to controls in urinary symptom score (P\xa0=\xa0.0006) and general health score (P\u2009<\u2009.0001) of the Ureteral Stent Symptom Questionnaire, total International Prostate Symptom Score (P\u2009<\u2009.00001), quality of life (P\u2009<\u2009.0001), analgesic use (P\xa0=\xa0.008), and readmission or visit to hospital due to discomfort (P\xa0=\xa0.001). Safety assessments including adverse events (P\xa0=\xa0.40) suggested that mirabegron was well tolerated.\n\n\nCONCLUSIONS\nThe present meta-analysis shows that mirabegron is an effective and safe treatment for relieving ureteral stent-related symptoms with a low occurrence of adverse events.