Comparison of the Effect of Photodynamic Therapy and Topical Corticosteroid on Oral Lichen Planus Lesions.

Abstract

OBJECTIVE\nIn this study, the effect of photodynamic therapy with topical corticosteroid in oral lichen planus patients was compared.\n\n\nMATERIALS AND METHOD\nIn this randomized double blind clinical trial, 8 patients with bilateral oral OLP lesions were recruited. Toluidine blue was applied on the lesions of both sides; a 660nm diode laser InGaAlP was irradiated for 10 min (power: 25mW, fluence: 19.23 J/cm2 , probe cross-section: 0.78 cm2 ) for three sessions. In the control side of the oral mucosa, only sham laser was used. Follow up sessions were held on week 3 and 7. In week 3, oral paste triamcinolone acetonide 0.1% was prescribed. Response rates were assessed clinically by VAS, Thongprasom sign scoring, clinical severity index, efficacy indices, and the amount of reduction in the size of the lesions. Mann-Whitney test was used to evaluate the treatment outcomes.\n\n\nRESULTS\nIn spite of control side, all scores improved significantly between session 0 and4 for the intervention side. The differences of changes in almost all scores between session 0 and 4 in both intervention and control sides were significantly considerable (p value<0.05).\n\n\nCONCLUSION\nPhotodynamic therapy can be used as an alternative therapy alongside standard methods or as a new modality for refractory OLP. This article is protected by copyright. All rights reserved.