Characterization of proinsulin‐specific regulatory T cells in type 1 diabetes at different ages of onset

Abstract

Regulatory T cells (Tregs) play an important role in maintaining tolerance to self‐antigens. Defects in the frequency and function of polyclonal Tregs have been reported in type 1 diabetes (T1D). However, characteristics of proinsulin (PI)‐specific Tregs in human T1D have not yet been explored. Therefore, we aimed to characterize PI‐specific Tregs in two distinct pathophysiological subtypes of T1D, juvenile‐onset T1D (JOT1D) and adult‐onset T1D (AOT1D), distinguished by the age of onset.