Hepatic macrosteatosis in the US pediatric deceased liver donor population.

Abstract

INTRODUCTION\nThe pediatric obesity epidemic is associated with early development of hepatic macrosteatosis, a hallmark of non-alcoholic fatty LI disease, which is thought to be more rapidly progressive in children than adults. Macrosteatosis in adult allografts is associated with allograft loss, but this has not been examined in pediatric donors.\n\n\nMETHODS\nWe studied all pediatric potential whole LI donors (2005-2018) who had a LI biopsy in the SRTR (n\xa0=\xa0862) and whose LI was transplanted (n\xa0=\xa0862). Macrosteatosis was abstracted from biopsy reports and compared to values in the SRTR standard analytic file. Recipients of macrosteatotic pediatric allografts were matched 1:1 to recipients of non-macrosteatotic pediatric allografts by propensity score matching on donor/recipient variables. All-cause allograft loss was estimated via Kaplan-Meier analysis and Cox proportional hazards model.\n\n\nRESULTS\nFrom 2005 to 2018, the proportion of pediatric donors (age ≥2\xa0years) with obesity increased (14.8% to 21.7%; p\xa0<\xa0.001), as did the proportion of pediatric deceased whole LI-only donor allografts with macrosteatosis (n\xa0=\xa010\xa0648; 1.8% to 3.9%; p\xa0<\xa0.001). The median degree of macrosteatosis among macrosteatotic donors was 10% (IQR 5-30). There were no significant differences in all-cause allograft loss between recipients of pediatric LI allografts with and without macrosteatosis at 90\xa0days (p\xa0=\xa0.11) or 1\xa0year (p\xa0=\xa0.14) post-transplant in Kaplan-Meier analysis or a Cox proportional hazards model (p\xa0>\xa0.05).\n\n\nCONCLUSION\nObese pediatric LI donors have increased over time and were more likely to have hepatic macrosteatosis; however, pediatric macrosteatosis did not appear to adversely affect recipient outcomes.