Pediatric transplantation | 2021
Acute kidney disease predicts chronic kidney disease in pediatric non-kidney solid organ transplant patients.
Abstract
BACKGROUND\nAcute kidney disease (AKD) is defined as impaired kidney function present for <90\xa0days with or without an acute kidney injury (AKI) event. Adults with AKD have an increased risk for progression to chronic kidney disease (CKD) and mortality. There are no data on the epidemiology of AKD in children after transplant. The aim of this study was to evaluate the incidence and risk factors for AKI, AKD, and CKD in children after transplantation.\n\n\nMETHODS\nThis is a retrospective cohort study of all children undergoing non-kidney solid organ transplant between 2011 and 2019 at UPMC Children s Hospital of Pittsburgh. AKI and AKD were defined using the Kidney Disease Improving Global Outcomes criteria. Patients with a new estimated glomerular filtration rate <60\xa0ml/min/1.73m2 persisting for >3\xa0months met criteria for new CKD. Variables associated with AKI, AKD, and CKD were analyzed.\n\n\nRESULTS\nAmong 338 patients, 37.9% met criteria for severe AKI, 13% for AKD, and 8% for a new diagnosis of CKD. Stage 3 AKI was independently associated with AKD (OR: 5.35; 95% CI: 2.23-12.86). Severe AKI was not associated with new-onset CKD, whereas AKD was associated with new-onset CKD (OR: 29.74; CI: 11.22-78.82).\n\n\nCONCLUSION\nAKD may be superior to AKI in predicting risk of CKD in children after non-kidney solid organ transplantation.