Detection of multicentric breast cancer using dedicated breast PET

Abstract

A 72‐year‐old woman with a history of left‐sided invasive mammary carcinoma was undergoing follow‐up 2 years after lumpectomy. She had a concomitant diagnosis of multiple myeloma (MM), and was re‐ ceiving chemotherapy for MM. A PET/CT scan with F‐18 FDG was negative for breast disease. The patient then underwent unilateral imaging of the left breast using a dedicated breast PET (db‐PET) system (Mammi‐PET, Oncovision, Valencia, Spain). The db‐PET scan demonstrated four focal areas of hypermetabolic activity within the left breast (Figure 1). Breast MRI was contraindicated. Hence, she underwent a mo‐ lecular breast imaging (MBI) scan with Tc‐99m sestamibi to fur‐ ther evaluate the db‐PET findings. The MBI scan showed six focal areas of moderate to marked radiotracer uptake in the left breast, five in the central and inferior breast and one superiorly (Figure 2). No suspicious radiotracer uptake was seen in the right breast. Following the MBI study, tomosynthesis demonstrated three irregular spiculated masses in the lower inner left breast and a sub‐ tle focal asymmetry in the superior breast (Figure 3). Diagnostic