A retrospective cost analysis of the frequency and cost of transfusion premedications

Abstract

Acetaminophen and diphenhydramine are routinely administered to prevent febrile non‐hemolytic and allergic blood transfusion reactions despite multiple randomized controlled trials demonstrating that this practice lacks efficacy. As a result, patients are exposed to the adverse effects of these medications and their financial burdens with no expected benefit. The aim of this study was to quantify the frequency and cost of transfusion premedications in patients with acute myeloid leukemia (AML).