Hypothetical protein gene1038 contributes to colistin resistance in Aeromonas hydrophila.

Abstract

Inhibition of vital respiratory enzymes, such as NADH: ubiquinone oxidoreductase (complex I), type II NADH-quinone oxidoreductases (NDH-2), and malate: quinone oxidoreductase, in the inner membrane, is a secondary antibacterial mechanism of colistin (1-3). However, colistin resistance mechanisms associated with this secondary mode of action of colistin have rarely been reported. Herein, we confirmed that the hypothetical protein gene1038 was associated with colistin resistance in Aeromonas hydrophila by reducing antibiotic function in the inner membrane, providing novel knowledge on the generation of colistin resistance.