Infection and Immunity | 2021
Articles of Significant Interest in This Issue
Abstract
Role of Humoral Immunity in Whole-Cell Vaccine-Mediated Protection against Pseudomonas aeruginosa Pseudomonas aeruginosa can cause a wide range of multidrug-resistant infections. However, there is currently no licensed P. aeruginosa vaccine. Understanding the required immune response to confer protection can help develop future vaccines and therapeutics against this bacterium. Sen-Kilic et al. (e00451-20) characterize mechanistic correlates of protection provided by whole-cell vaccination against P. aeruginosa during infection. Their data indicate that B cells and antibodies play a crucial role in whole-cell vaccine-induced protection against P. aeruginosa. In particular, their findings suggest that T cell-independent antibody production induced by whole-cell vaccination is sufficient for bacterial clearance during acute lung pneumonia.