Further Mechanisms and Locations in Which Antisporozoite Antibodies Neutralize Malaria Sporozoites

Abstract

Having worked in this area for many years, I read with much interest the recent article “Antibody-Mediated Protection against Plasmodium Sporozoites Begins at the Dermal Inoculation Site” by Flores-Garcia et al. (1). It is now universally recognized, as described by the authors, that mosquitoes inject most of their sporozoites into extravascular skin tissue rather than directly into blood vessels (2, 3). From there, they migrate through the dermis to …