Silver Nanocomposites Based on Copolymers N,N-Dialyl-Nʹ-acylhydrazines with Acrylic Monomers

Abstract

Copolymers of N,N-diallyl-Nʹ-acetylhydrazine and N,N-diallyl-Nʹ-benzoylhydrazine with acrylic acid, acrylonitrile, and acrylamide were synthesized by radical copolymerization in the presence of a radical initiator azobisisobutyronitrile. The borohydride method was used to produce new polymer nanocomposites containing silver nanoparticles 31–55 nm in size, stabilized by synthesized copolymers of N,N-diallyl-Nʹ-acylhydrazines. The presence of heteroatomic fragments and functional groups (carboxyl, amide, nitrile, acetyl, benzoyl, hydrazine) in the polymer chain promotes specific interaction with silver particles, regulating the particle size at the nanoscale and ensuring their uniform distribution in the polymer matrix. Structural features of nanocomposites were investigated using UV, IR, NMR spectroscopy and scanning electron microscopy. The produced nanocomposites exhibit cytotoxic activity against MS melanoma cells and RD rhabdomyosarcoma cells and are promising as new-generation drugs intended for the treatment of cancerous tumors.