Synthesis and Properties of 1,3-Disubstituted Ureas and Their Isosteric Analogs Containing Polycyclic Fragments: X. 1-[1-(4-Isobutylphenyl)ethyl]-3-R-ureas

Abstract

The reactions of 1-isobutyl-4-(1-isocyanatoethyl)benzene with various amines and of 1-(4-isobutylphenyl)ethanamine with halogenated aromatic isocyanates gave a series of ureas containing an ibuprofen fragment in their structure. The yields of the target product yields were up to 95%. The synthesized ureas are potential multitarget inhibitors of soluble epoxide hydrolase (sEH) and cyclooxygenase (COX).