FRI0043\u2005CHARACTERISTICS OF PATIENTS WITH RHEUMATOID ARTHRITIS ADMITTED TO AN INTENSIVE CARE UNITIN SPAIN SINCE 2005–2015. TREND-AR STUDY

Abstract

Objectives: To analyse the clinical features of patients with Rheumatoid Arthritis (RA) that were admitted to an Intensive Care Unit (ICU) from January 2005 to December 2015. Methods: A retrospective observational populational study was conducted analysing the national database that includes the Minimum Basic Data Sets (MBDSs) of admissions of RA patients to an ICU during the 2005-2015 period. Demographic characteristics, length of stay, clinical course, outcome and the MBDS codes for the main reason of admission were recorded. The cases were detected by the presence of their CIE-9 codes in the primary or secondary diagnoses. Statistical analysis was performed with Stata 15.0 software. Results: During the 11 years of the study, a total of 2719 RA patients required 2806 admissions to an ICU. Average age was 69.7 ± 10.8 years and women constituted 58.5% of the cases. 30% of the patients admitted to an ICU had required ≥ 3 previous admissions and 11% required readmission within the next 30 days. Average Charlson index was 2.33 ± 1.4. Average length of stay was 9.3 ± 14 days and 64.2% died in the ICU during hospitalization. The main causes of hospitalization were cardiovascular events (45.7%), lung diseases (16%) and infections (10%). In the univariant analysis mortality was significantly increased in patients presenting infections (90%), lung disease (89%), severe hepatopathy defined by ascites and/or encephalopathy and/or gastrointestinal bleeding (88%), nephropathy/kidney disease (73%) and a higher Charlson index (2.4 vs 2.2). Multivariant analysis showed that mortality was increased among patients presenting respiratory complications and infections. Conclusion: The most frequent hospitalization causes for patients with Rheumatoid Arthritis in Spain between 2005 and 2015 were cardiovascular, pulmonary and infectious diseases. RA patients that were admitted to the ICU showed an increased mortality. This increased mortality was mainly found in patients presenting respiratory or infectious conditions. \nDisclosure of Interests: None declared