POS0124\u2005QUALITY OF LIFE FOR PATIENTS WITH KNEE OSTEOARTHRITIS WITH OR WITHOUT PAIN SENSITIZATION

Abstract

Patients with central sensitization (CS) may have poorer quality of life (QOL).We aim to evaluate whether different ways of classifying CS have an impact on a patient’s QOL among patients with knee osteoarthritis (KOA).We use the baseline pre-operative data from a cohort of consecutive KOA patients enlisted for knee replacement surgery (1). We collected demographics, number and position of painful sites of body. Quality of life was assessed by the Medical Outcome Survey Short-Form 36 (SF-36). Pain pressure threshold was measured at volar side of right forearm. We classify CS using three sets of criteria: 1). widespread pain (pain involving both upper/ lower trunk, and both side of body), 2). lowest 10th percentile of pressure pain threshold (PPT) measured at the forearm and 3) the painDETECT questionnaire >=13/38.Of 233 patients (79.8% women) with complete data set for analysis, mean (standard deviation, SD) age was 66.0 (8.3) years. 15.5%, 25.8%, and 4.7% of patients were classified as having CS by widespread pain, low PPT and painDETECT criteria. KOA patients with CS have poorer QoL compared with those without. Low PPT identified patients with poorer general health, while widespread pain and PainDETECT criteria identified patients with poorer QoL in more domains including vitality mental health (Table 1).Table 1.Quality of life comparing patients with or without CSWidespread painlowest 10th percentile of forearm PPTPainDETECT >=13/38No (n = 197)Yes (n= 36)No (n= 206)Yes (n= 27)No (n= 222)Yes(n= 11)SF-Physical functioning39.0 (21.8)32.6 (19.0)38.7 (21.8)32.8 (17.8)38.8 (21.3)22.3 (19.2)*SF-Role physical21.6 (33.3)8.3 (22.4)*20.3 (32.2)13.9 (32.0)19.7 (32.6)15.9 (23.1)SF-Bodily pain36.3 (19.5)28.1 (14.0)*35.1 (19.5)34.0 (14.7)35.5 (19.1)24.2 (13.3)SF-General health68.9 (21.1)64.6 (20.3)69.4 (20.6)59.3 (22.4)*68.7 (20.7)58.4 (25.7)SF-Vitality score69.7 (22.4)59.3 (20.4)**68.8 (22.5)63.1 (21.1)69.0 (21.8)51.8 (29.2)*SF-Social functioning57.7 (37.2)48.3 (39.2)57.3 (38.0)48.1 (33.7)56.7 (37.7)47.7 (42.1)SF-Role emotion86.1 (34.4)86.1 (33.2)86.7 (33.5)79.0 (38.3)86.9 (32.9)63.6 (50.5)SF-Mental health82.4 (16.2)77.4 (19.2)82.2 (16.8)77.8 (15.8)82.2 (16.3)70.2 (22.2)*Physical component score32.5 (10.1)30.3 (8.0)32.4 (9.8)30.6 (9.7)32.4 (9.9)28.8 (8.7)Mental component score53.0 (10.5)48.3 (10.0)*52.7 (10.6)48.5 (9.2)52.6 (10.2)44.2 (13.7)*** p<0.05; **p<0.01KOA patients who have CS have poorer QoL compared to those without. Different criteria defined patients with different pattern of QoL impacts. In general, KOA patients who have CS have poorer QoL compared to those without. This highlight the importance of additional impact of CS to QoL[1]Leung YY, Lim Z, Fan Q, et al. Pre-operative pressure pain thresholds do not meaningfully explain satisfaction or improvement in pain after knee replacement: a cohort study. Osteoarthritis and cartilage 2019;27(1):49-58.None declared