P56\u2005Higher body mass index (BMI) is associated with improved continuous positive airway pressure (CPAP) outcomes in patients with hypoxic respiratory failure secondary to COVID-19

Abstract

P56 Table 1Demographics, co-morbidities, investigations, observations and Continuous Positive Airway Pressure (CPAP) data for all patientsVariable CPAP Success CPAP Failure p - value N 9 32 - Demographics Age 54 ± 15 4 61 ± 9 9 0 104 Male Sex (%) 6 (66 7) 21 (65 6) 0 954 Ethnicity – BAME (%) 3 (33 3) 22 (68 7) 0 054 BMI* 30 3 (28 1 – 37 0) 24 9 (22 9 – 28 1) 0 005 Comorbidities Hypertension (%) 5 (55 5) 19 (59 4) 0 837 Diabetes (%) 5 (55 5) 10 (31 3) 0 181 Ischaemic Heart Disease (%) 1 (11 1) 1 (3 1) 0 326 Hypercholesterolaemia (%) 5 (55 5) 8 (25) 0 082 Respiratory disease (%) 0 (0) 4 (12 5) 0 256 Smoking history (%) 0/8 (0) 12 (37 5) 0 023 Respiratory function prior to CPAP SpO2%* 91 (75 8 – 97 2) 90 (86 – 93) 0 203 FiO2% 71 7 ± 17 0 78 1 ± 13 8 0 251 Respiratory Rate 32 9 ± 8 4 33 4 ± 7 4 0 852 CPAP Number of days* 2 (1 5 – 3) 1 (1–2) 0 103 Max PEEP* 9 75 (9 13 – 10) 10 (10–12) 0 255 *Non-parametric data, therefore median and interquartile ranges presented All other data are presented as means ± standard deviationAbbreviations: CXR – Chest X-rayConclusionIn our small cohort, CPAP alone was successful in 22% This was lower than another recent study (1), however, our patient cohort had more co-morbidities Patients with a higher BMI had significantly greater CPAP success This may be due to an increased number of undiagnosed OSA in this cohort and merits further investigation While smokers had an increased risk of CPAP failure, none of the patients were current smokers and there was limited data on pack-year history Further studies are necessary to identify factors that may point to greater CPAP success during COVID-19 ReferenceNightingale R , et al BMJ Open Respir Res 2020 Jul;7(1):e000639