SAT0251\u2005SEX- AND AGE-RELATED DIFFERENCES IN CLINICAL MANIFESTATIONS OF BEHÇET’S DISEASE IN A LARGE COHORT OF CHINA PATIENTS

Abstract

Background: Behçet’s disease (BD) is a systemic vasculitis with multiple symptoms such as recurrent oral and/or genital ulceration, skin lesions, ocular lesions, and other systems affection. Studies have been conducted to reveal sex- and age-related differences in clinical characteristics of BD in several countries1-5, but up to now sex and age influence for Chinese BD patients is very limited. Objectives: This study aimed to investigate the clinical phenotypes of BD concerning gender and age in China. Methods: We retrospectively reviewed the medical records of BD patients followed up in the Departments of Rheumatology, Peking Union Medical College Hospital (PUMCH) between March 2014 and January 2019. Demographics, clinical features at onset and during follow-up were obtained from a review of medical records. Results: A total of 489 BD patients were included in our database: 286 males (58.49%) and 203 females (41.51%) (Sex ratio M/F was 1.41), with a median age of 34 years (interquartile range: 28-44 years). Recurrent oral ulceration was the most common manifestation (96.32%), followed by genital ulceration (71.17%), skin lesions (57.67%), vascular lesions (25.36%), and ocular involvement (24.13%). Gastrointestinal (GI) involvement (15.13%), positive pathergy test (14.11%), and neurological involvement (5.93%) were less frequently observed. The comparative study between males and females revealed that ocular lesions (28.67% vs 17.73%, P=0.005), vascular lesions (31.47% vs 16.75%, P< 0.001) and positive pathergy test (17.83% vs 8.37%, P=0.002) were more common in male, while genital ulceration was more common in female (64.34% vs 80.79%, P<0.001). Regarding age difference, ocular lesions (P=0.017) were more frequently observed in younger patients, while vascular lesions(P=0.024) and GI symptoms(P=0.010) were more common in older patients. Gender differences of these manifestations were more prominent in certain age groups among 20-50 years old than other groups. Conclusion: These analyses support that the clinical features of Chinese BD were different depending on sex and age. References [1] Bonitsis, NG. et al. Gender-specific differences in Adamantiades-Behçet’s disease manifestations: an analysis of the German registry and meta-analysis of data from the literature. Rheumatology 2015. 54, 121. [2] Ishido, T. et al. Clinical manifestations of Behçet’s disease depending on sex and age: results from Japanese nationwide registration. Rheumatology 2017. 56,1918-1927. [3] Ugurlu, N. et al. The natural course and factors affecting severity of Behçet’s disease: a single-center cohort of 368 patients. Rheumatol Int 2015. 35, 2103-7. [4] Khabbazi A, et al. Demographic and clinical features of Behcet’s disease in Azerbaijan. Int J Rheum Dis 2014. 21,1114-1119. [5] Hamzaoui, A. et al. Comparison of clinical features of Behcet disease according to age in a Tunisian cohort. Acta Med Iran 2014,52,748. Disclosure of Interests: None declared