Prehospital time and mortality in patients requiring a highest priority emergency medical response: a Danish registry-based cohort study

Abstract

Objective To examine the association between time from emergency medical service vehicle dispatch to hospital arrival and 1-day and 30-day mortality. Design Register-based cohort study. Setting North Denmark Region (≈8000\u2009km2, catchment population ≈600 000). Participants We included all highest priority dispatched ambulance transports in North Denmark Region in 2006–2012. Interventions Using logistic regression and the g-formula approach, we examined the association between time from emergency dispatch to hospital arrival and mortality for presumed heart, respiratory, cerebrovascular and other presumed medical conditions, as well as traffic or other accidents, as classified by emergency dispatch personnel. Main outcome measures 1-day and 30-day mortality. Results Among 93\u2009167 individuals with highest priority ambulances dispatched, 1948 (2.1%) were dead before the ambulance arrived and 19\u2009968 (21.4%) were transported to the hospital under highest priority (median total prehospital time from dispatch to hospital arrival 47\u2009min (25%–75%: 35–60\u2009min); 95th percentile 84\u2009min). Among 18\u2009709 with population data, 1-day mortality was 10.9% (n=2038), and was highest for patients with dyspnoea (20.4%) and lowest for patients with traffic accidents (2.8%). Thirty-day mortality was 18.3% and varied between 36.6% (patients with dyspnoea) and 3.7% (traffic accidents). One-day mortality was not associated with total prehospital time, except for presumed heart conditions, where longer prehospital time was associated with decreased mortality: adjusted OR for >60\u2009min vs 0–30\u2009min was 0.61 (95% CI 0.40 to 0.91). For patients with dyspnoea, OR for >60\u2009min vs 0–30\u2009min was 0.90 (95% CI 0.56 to 1.45), for presumed cerebrovascular conditions OR 1.41 (95% CI 0.53 to 3.78), for other presumed medical conditions OR 0.84 (95% CI 0.70 to 1.02), for traffic accidents OR 0.65 (95% CI 0.29 to 1.48) and for other accidents OR 0.84 (95% CI 0.47 to 1.51). Similar findings were found for 30-day mortality. Conclusions In this study, where time from emergency dispatch to hospital arrival mainly was <80\u2009min, there was no overall relation between this prehospital time measure and mortality.