EP267\u2005Synchronous primary cervical and fallopian tube carcinoma: a case report

Abstract

Introduction/Background Multiple primary malignant tumors (MPMT) are defined as two or more independent primary malignancies from different sites and are of different histologies in the same individual2. Incidence of MPMTs ranges from 0.4–21%7. Though a primary fallopian tube carcinoma (PFTC) is a rare malignancy with only <1% of female genital malignancies, a synchronous cervical and fallopian tube carcinoma is a more uncommon clinical entity with only a few documented cases worldwide. Methodology This is a case of a 64-year old nulligravid, who presented with post-menopausal bleeding. She underwent fractional curettage. Histopathology of the endometrial scrapings and endocervical tissue showed Squamous Cell Carcinoma, Large Cell Non- Keratinizing. She subsequently underwent exploratory laparotomy for Stage IB cervical carcinoma vs a primary endometrial carcinoma with cervical extension. Contemplated radical hysterectomy was abandoned because of the dense adhesions to the bladder. The fallopian tubes were noted to be bulbous with multiple fleshy papillations, hence bilateral salpingo-oophorectomy, biopsy of the tumor implant, excision of the left external lymph node and infracolic omentectomy was done. Results Histopathology showed High-grade Papillary Serous carcinoma of the fallopian tubes with lymphovascular invasion; Metastatic Papillary Carcinoma of bilateral ovaries and external iliac lymph nodes. Final staging according to FIGO system revealed IB1 cervical carcinoma and fallopian tube carcinoma stage IIIB. Conclusion She completed 6 cycles of Carboplatin-Paclitaxel regimen. Intracavitary brachytherapy was delivered in four fractions of 6 Gy. Patient has remained in follow-up, and at 8 months, there has been no documented evidence of recurrent disease. Disclosure Nothing to disclose. Abstract EP267 Figure 1 Microsection from endocervical scrapping showing malignant neoplasm Abstract EP267 Figure 2 Left fallopian tube hyperchromatic nuclei, exhibiting hobnailing and with basophilic cytoplasm consistent with Papillary Serous Carcinoma.