EP924\u2005Clinical characteristics predictive of optimal primary cytoreduction in epithelial ovarian malignancy: a five-year retrospective study in a tertiary government hospital

Abstract

Introduction/Background To determine the clinical characteristics predictive of optimal cytoreduction among women with epithelial ovarian malignancy who underwent cytoreductive surgery in a tertiary government hospital. Methodology This retrospective cohort study identified 218 patients with epithelial ovarian cancer who underwent primary cytoreductive surgery in a tertiary government hospital between January 2013 to December 2017. Demographic, imaging, CA-125, surgico-pathologic data were collected. Outcome measures included incidence of optimal cytoreduction and factors affecting its occurrence. Descriptive and inferential analysis were done to estimate odds ratio with 95% confidence interval and p-values. Univariate and multivariate logistic regression analysis were done. Results A total of 145 patients had optimal cytoreduction while 73 had non-optimal cytoreduction. A simple logistic regression analysis showed that extent of disease, presence of ascites, CA-125 value, size of tumor, stage and histologic types were independent predictors of optimal cytoreduction. After adjusting the effects of covariates on multiple logistic regression analysis, mid preoperative extent of disease, and low or mid intra-operative extent of disease were associated with more than 900 and 100 times increased odds of optimal cytoreduction (p-values <0.001). Conclusion Pre-operative mid extent of disease and intraoperative low or mid extent of disease were statistically significant predictors of optimal cytoreduction. Disclosure Nothing to disclose.