Journal of Neurology, Neurosurgery & Psychiatry | 2021
Prospective study of cancer survival in patients with HuD-antibody-associated paraneoplastic neurological disorders
Abstract
INTRODUCTION The appearance of a paraneoplastic neurological disorder (PND) with Huantibodies, often before tumour detection, together with spontaneous tumour regression in a few patients, suggests that immune responses to HuD, possibly mediated by cytotoxic Tcells, could be beneficial to the patient. Nevertheless, in previous retrospective studies, survival in Huantibodyassociated PNDs (HuAb/ PNDs) in general was similar to those in patients with smallcell lung cancer (SCLC) without neurological illness. 3 Here we studied, for the first time prospectively, tumour outcomes in a large series of patients with HuAb/ PNDs, comparing with contemporaneous patients with SCLC without neurological symptoms.