Journal of Diabetes Research | 2019

Sleep-Disordered Breathing Is Associated with Metabolic Syndrome in Outpatients with Diabetes Mellitus Type 2



Background Metabolic syndrome (MS) and sleep-disordered breathing (SDB) are highly prevalent in patients with diabetes mellitus type 2 (DM2). The present study examined whether there is an independent association between SDB and MS in a sample of outpatients with DM2. Methods MS was determined in 679 patients of the DIACORE-SDB substudy, a study of outpatients with DM2. According to the National Cholesterol Education Program (NCEP) criteria, MS is defined by at least three of the following five criteria: waist circumference of >102\u2009cm (men)/>88\u2009cm (women), blood pressure of ≥130/85\u2009mmHg, a fasting triglyceride level of >150\u2009mg/dl, high-density lipoprotein (HDL) of <40\u2009mg/dl (men)/<50\u2009mg/dl (women), and a fasting glucose level of ≥110\u2009mg/dl. The apnea-hypopnea index (AHI) was assessed with a 2-channel ambulatory monitoring device and used to define the severity of SDB (AHI < 15.0: no/mild SDB; AHI 15.0-29.9: moderate SDB; AHI ≥ 30.0: severe SDB). Results 228 (34%) of the 679 participants (mean age 66 years, mean body mass index (BMI) 31.2\u2009kg/m2, and mean AHI 14/hour) had SDB. MS was significantly more frequent in patients with more severe SDB (no/mild SDB vs. moderate SDB vs. severe SDB: 72% vs. 79% vs. 85%, respectively, p = 0.038). Logistic regression analysis adjusted for sex, age, obesity (BMI ≥ 30 kg/m2), and the HOMA index showed a significant association between the AHI and the presence of MS (OR (95%CI) = 1.039 (1.011; 1.068); p = 0.007). Further, male sex, obesity, and the HOMA index were significantly associated with MS. Conclusion SDB is significantly and independently associated with MS in outpatients with DM2.

Volume 2019
Pages None
DOI 10.1155/2019/8417575
Language English
Journal Journal of Diabetes Research

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