Journal of Ophthalmology | 2019
CLU Polymorphisms in Patients with Pseudoexfoliation Syndrome in Polish Population
Abstract
Purpose To evaluate CLU polymorphisms in patients with pseudoexfoliation syndrome. Materials and Methods We studied 81 patients (23 males and 58 females, the median age 76\u2009years) and 91 control subjects (27 males and 64 females, the median age 75\u2009years). Genotypes of the CLU polymorphisms (SNPs), rs3087554 and rs2279590, were determined using a commercially available validated genotyping assays. The χ2 test was performed to compare patient and control groups for possible associations between SNP genotype/allele frequency and disease state. Results There were no significant differences for both allele and genotype frequencies between PEX patients and controls for rs3087554 and rs2279590 polymorphisms. The haplotypes distribution shows statistically significant difference between groups (p=0.03). The haplotype (CT) more often was found in controls than in PEX patients, conferring an 18-fold decreased risk to the disease. Conclusion Our results indicate that CLU variants may contribute to the risk of PEX in the Polish population.