Association between Obstructive Sleep Apnea and Type 2 Diabetes Mellitus: A Dose-Response Meta-Analysis

Abstract

Materials and Methods We screened four databases (PubMed, Embase, Cochran Library, and CNKI) for the observational studies about the OSA and T2DM. Studies were collected from database establishment to October 2020. We performed a traditional subgroup meta-analysis. What is more, linear and spline dose-response models were applied to assess the association between apnea-hypopnea index (AHI), an indicator to evaluate the severity of OSA, and the risk of T2DM. Review Manager, version 5.3, software and Stata 16.0 were used for the analysis. Result Seven observational studies were included in the research. We excluded a study in the conventional meta-analysis. In the subgroup analysis, mild-dose AHI increased the risk of T2DM (odds ratio\u2009=\u20091.23, 95% confidence interval\u2009=\u20091.06–1.41, P\u2009<\u20090.05). Moderate-dose AHI increased the risk of T2DM with a higher odds ratio (OR\u2009=\u20091.35, 95% CI\u2009=\u20091.13–1.61, P\u2009<\u20090.05). Moderate-to-severe-dose AHI increased the risk of T2DM with a higher odds ratio (OR\u2009=\u20092.14, 95% CI\u2009=\u20091.72–2.67, P\u2009<\u20090.05). Severe-dose AHI increased the risk of T2DM with a higher odds ratio (OR\u2009=\u20092.19 95% CI\u2009=\u20091.30–3.68, P\u2009<\u20090.05). Furthermore, the spline and linear dose-response meta-analysis results revealed that the risk of T2DM increased with increasing AHI values. Conclusion Through the dose-response meta-analysis, we found a potential dose-response relationship existed between the severity of OSA and the risk of T2DM. This relationship in our passage should be considered in the prevention of T2DM in the future.