Computed Tomography Angiography under Deep Learning in the Treatment of Atherosclerosis with Rapamycin

Abstract

The clinical characteristics and vascular computed tomography (CT) imaging characteristics of patients were explored so as to assist clinicians in diagnosing patients with atherosclerosis. 316 patients with atherosclerosis who were hospitalized for emergency treatment were treated with rapamycin (RAPA) in the hospital. A group of manually delineated left ventricular myocardia (LVM) on the patient s coronary computed tomography angiography (CCTA) were selected as the region of interest for imaging features extracted. The CCTA images of 80% of patients were randomly selected for training, and those of 20% of patients were used for verification. The correlation matrix method was used to remove redundant image omics features under different correlation thresholds. In the validation set, CCTA diagnostic parameters were about 40 times higher than the manually segmented data. The average dice similarity coefficient was 91.6%. The proposed method also produced a very small centroid distance (mean 1.058\u2009mm, standard deviation 1.245\u2009mm) and volume difference (mean 1.640), with a segmentation time of about 1.45\u2009±\u20090.51\u2009s, compared to about 744.8\u2009±\u2009117.49\u2009s for physician manual segmentation. Therefore, the deep learning model effectively segmented the atherosclerotic lesion area, measured and assisted the diagnosis of future atherosclerosis clinical cases, improved medical efficiency, and accurately identified the patient s lesion area. It had great application potential in helping diagnosis and curative effect analysis of atherosclerosis.