SCMAG: A Semisupervised Single-Cell Clustering Method Based on Matrix Aggregation Graph Convolutional Neural Network

Abstract

Clustering analysis is one of the most important technologies for single-cell data mining. It is widely used in the division of different gene sequences, the identification of functional genes, and the detection of new cell types. Although the traditional unsupervised clustering method does not require label data, the distribution of the original data, the setting of hyperparameters, and other factors all affect the effectiveness of the clustering algorithm. While in some cases the type of some cells is known, it is hoped to achieve high accuracy if the prior information about those cells is utilized sufficiently. In this study, we propose SCMAG (a semisupervised single-cell clustering method based on a matrix aggregation graph convolutional neural network) that takes into full consideration the prior information for single-cell data. To evaluate the performance of the proposed semisupervised clustering method, we test on different single-cell datasets and compare with the current semisupervised clustering algorithm in recognizing cell types on various real scRNA-seq data; the results show that it is a more accurate and significant model.