Can Biomarkers Guide Oncolytic Virus Immunotherapy?

Abstract

Defects in tumor cell IFNγ signaling is associated with resistance to immune checkpoint inhibitors. Recently, these defects were found to confer increased sensitivity to oncolytic virus infection. Differential expression of innate sensing elements in tumor cells may serve as predictive biomarkers of oncolytic virus immunotherapy in patients with cancer. See related article by Nguyen et al., p. 3432