Abstract 596: Association between an empirically-derived inflammatory lifestyle score and incident colorectal cancer

Abstract

Inflammation is often suggested as major pathway by which lifestyle influences the development of colorectal cancer (CRC). In the present analysis, we empirically derived an inflammatory lifestyle score (ILS) based on associations of nine lifestyle factors with serum levels of high-sensitivity C-reactive protein (hsCRP) and subsequently examined its association with incident CRC in the Cancer Prevention Study-II Nutrition Cohort. Lifestyle factors other than smoking were chosen a priori from the American Cancer Society’s Guidelines on Nutrition and Physical Activity for Cancer Prevention to include body mass index, physical activity, sedentary time, fruit/vegetable intake, variety of fruits/vegetables consumed, red/processed meat intake, ratio of whole to refined grains consumed, alcohol consumption, and smoking status. Reduced rank regression was used to create sex-specific lifestyle scores that correlate the nine lifestyle factors with hsCRP in a testing subset of 2,707 men and women with no history of cancer at the time of blood draw. In a validation subset (n=540), the derived ILS was positively correlated with serum hsCRP levels (r=0.19, p-value Citation Format: Mark Guinter, Susan Gapstur, W. Dana Flanders, Ying Wang, Erika Rees-Punia, Marjorie McCullough, Kassandra I. Alcaraz, Michael Pollak, Peter Campbell. Association between an empirically-derived inflammatory lifestyle score and incident colorectal cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 596.