Abstract PS6-35: Real world outcomes in elderly women with HER2 positive advanced breast cancer

Abstract

BackgroundThe development of anti-human epidermal growth factor receptor 2 (HER2) therapies has significantly improved disease outcomes in patients with HER2-positive advanced breast cancer (ABC). However, elderly patients are persistently under-represented in clinical trials, with only 2.4% of patients aged ≥75 years in the pivotal CLEOPATRA study. Despite a lack of research addressing treatment outcomes in elderly patients, advanced age at diagnosis is associated with a greater likelihood of receiving no initial systemic therapy for de novo metastatic breast cancer. Studies have also shown that older women diagnosed with metastatic breast cancer have a poorer prognosis and shorter life expectancy. We examined treatment patterns and outcomes in an elderly (defined as ≥70) ‘real world’ Australian population. MethodsData was extracted from the Treatment of Advanced Breast Cancer in the HER2-positive Australian Patient (TABITHA) multi-site clinical registry, and patients stratified according to age ( ResultsWe identified 319 patients, including 67 patients (21%) aged ≥70 years. Older patients were more likely to have an Eastern Cooperative Oncology Group performance status of ≥2 (16% vs 3%; p ConclusionElderly patients with HER2-positive ABC demonstrated shorter chemotherapy durations, poorer overall survival, and increased rates of adverse events despite having similar disease characteristics and treatment patterns. Prospective studies are required to improve outcomes in the elderly HER2 positive population. Citation Format: Nicole Evans, Angelyn Anton, Rachel Wong, Sheau Wen Lok, Richard De Boer, Laeeq Malik, Sally Greenberg, Belinda Yeo, Louise Nott, Gary Richardson, Ian M Collins, Javier Torres, Frances Barnett, Peter Gibbs, Bianca Devitt. Real world outcomes in elderly women with HER2 positive advanced breast cancer [abstract]. In: Proceedings of the 2020 San Antonio Breast Cancer Virtual Symposium; 2020 Dec 8-11; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2021;81(4 Suppl):Abstract nr PS6-35.