The Utility of Diffusion Weighted Imaging and Dynamic Contrast Enhanced MRI Techniques in Differentiation Between Benign and Malignant Uterine Masses

Abstract

The aim of the present study was to evaluate the role of diffusion weighted imaging (DWI) and dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) in the differentiation between benign and malignant endometrial, uterine and cervical masses. The study included 78 patients. All patients had uterine or cervical masses on ultrasound examination. All patients had conventional MRI, DWI, and DCE-MRI. The patients were classified into three groups: patients with endometrial masses, myometrial lesions and cervical masses. The mean ADC value of benign endometrial and myometrial lesions was higher significantly from malignant lesions (P value <0.001 and <0.001). The cut off value of ≤1.1×10-3mm2/sec as a predictor of malignant lesions yielded a sensitivity, specificity, PPV, NPV and accuracy of 89.65%, 91.54%, 88.67%, 92.41% and 95.21% respectively. The semi-quanitative parameters of DCE-MRI including the enhancement amplitude (EA), maximum slope (MS) and time of half rising (THR), all showed significant difference between the benign and malignant lesion in endometrial, myometrial and cervical lesions. In clinically and sonographically indeterminate endometrial, myometrial or cervical masses, DWI and DCE-MRI proved to be more accurate than conventional MRI in differentiation between benign and malignant masses, with the DWI and ADC value had more sensitivity and specificity especially in endometrial masses and should be included in the routine pelvic MRI. DCE-MRI should be reserved for still questionable cases after DWI and to study the vascularity of the lesions.