American Journal of Respiratory and Critical Care Medicine | 2019

PP2A: A Novel Target to Prevent Cathepsin S–mediated Damage in Smoking-induced Chronic Obstructive Pulmonary Disease

 
 

Abstract


1. Calfee CS, Delucchi K, Parsons PE, Thompson BT, Ware LB, Matthay MA; NHLBI ARDS Network. Subphenotypes in acute respiratory distress syndrome: latent class analysis of data from two randomised controlled trials. Lancet Respir Med 2014;2: 611–620. 2. Calfee CS, Delucchi KL, Sinha P, Matthay MA, Hackett J, Shankar-Hari M, et al.; Irish Critical Care Trials Group. Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial. Lancet Respir Med 2018;6:691–698. 3. Famous KR, Delucchi K, Ware LB, Kangelaris KN, Liu KD, Thompson BT, et al.; ARDS Network. Acute respiratory distress syndrome subphenotypes respond differently to randomized fluid management strategy. Am J Respir Crit Care Med 2017;195: 331–338. 4. Sinha P, Delucchi KL, Thompson BT, McAuley DF, Matthay MA, Calfee CS; NHLBI ARDS Network. Latent class analysis of ARDS subphenotypes: a secondary analysis of the statins for acutely injured lungs from sepsis (SAILS) study. Intensive Care Med 2018;44: 1859–1869. 5. Bos LD, Schouten LR, van Vught LA, Wiewel MA, Ong DSY, Cremer O, et al.; MARS Consortium. Identification and validation of distinct biological phenotypes in patients with acute respiratory distress syndrome by cluster analysis. Thorax 2017;72: 876–883. 6. Sinha P, Calfee CS. Phenotypes in acute respiratory distress syndrome: moving towards precision medicine. Curr Opin Crit Care 2019;25:12–20. 7. Bos LDJ, Scicluna BP, Ong DSY, Cremer O, van der Poll T, Schultz MJ; MARS Consortium. Understanding heterogeneity in biological phenotypes of acute respiratory distress syndrome by leukocyte expression profiles. Am J Respir Crit Care Med 2019;200:42–50. 8. Kangelaris KN, Prakash A, Liu KD, Aouizerat B, Woodruff PG, Erle DJ, et al. Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS. Am J Physiol Lung Cell Mol Physiol 2015; 308:L1102–L1113. 9. Kim EK, Choi EJ. Pathological roles of MAPK signaling pathways in human diseases. Biochim Biophys Acta 2010;1802:396– 405. 10. Recio C, Lucy D, Purvis GSD, Iveson P, Zeboudj L, Iqbal AJ, et al. Activation of the immune-metabolic receptor GPR84 enhances inflammation and phagocytosis in macrophages. Front Immunol 2018;9:1419. 11. Rella JM, Jilma B, Fabry A, Kaynar AM, Mayr FB. MMP-8 genotypes influence the inflammatory response in human endotoxemia. Inflammation 2014;37:451–456. 12. Prescott HC, Calfee CS, Thompson BT, Angus DC, Liu VX. Toward smarter lumping and smarter splitting: rethinking strategies for sepsis and acute respiratory distress syndrome clinical trial design. Am J Respir Crit Care Med 2016;194: 147–155. 13. Sweeney TE, Thomas NJ, Howrylak JA, Wong HR, Rogers AJ, Khatri P. Multicohort analysis of whole-blood gene expression data does not form a robust diagnostic for acute respiratory distress syndrome. Crit Care Med 2018;46:244–251. 14. Davenport EE, Burnham KL, Radhakrishnan J, Humburg P, Hutton P, Mills TC, et al. Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study. Lancet Respir Med 2016;4:259–271.

Volume 200
Pages 6 - 8
DOI 10.1164/rccm.201901-0219ED
Language English
Journal American Journal of Respiratory and Critical Care Medicine

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