American Journal of Respiratory and Critical Care Medicine | 2021
Does Heart Rate Play a Role in Cardiovascular Outcome in Patients with Obstructive Sleep Apnea?
Abstract
are dynamic and vary depending on the clinical context. Thus, these results should be interpreted with caution. Attending physicians diagnosed fluid overload and also prescribed NUF rates, which were not protocol based. However, this reflects real-world practice. Finally, we calculated NUF rates as an average of total daily NUF, which normally has variation during therapy. Conclusions. In patients undergoing CRRT, high NUF rates were associated with increased mortality compared with moderate NUF rates. This association appeared attenuated but not removed by the more negativeDFB typically associatedwith higherNUF rate, especially in the setting of baseline fluid overload. These findings are hypothesis generating and provide preliminary support for the hypothesis that a negative mean DFB during CRRT might be safe when achieved with moderate rates of NUF. However, future randomized interventional trials are required to confirm these findings. n