Sleep Medicine

Abstract

s L e e P M e D iC in e Presentation schedule is subject to change. The Official Program Abstracts supplement does not reflect changes made after August 13, 2021. on treatment failure in AERD; and demonstrate the complexity of managing patients with AERD. As biologics have only recently been approved for use in polyps, the study needed more follow-up data to be robust. Methods: This is a retrospective chart review conducted at a tertiary care hospital between 2011 to 2021 by performing a search through the electronic medical record for patients with an ICD code diagnosis of 2 out of 3 AERD criteria: asthma, aspirin, and nonsteroidal anti-inflammatory drug sensitivity and sinonasal polyposis. This was followed by a manual chart review to include patients with all 3 criteria. They were grouped into patients whose symptoms were adequately managed by single treatment modality (group A) or needed change in treatment modality (group B). Demographic data were analyzed. Results: Of the 72 (N) patients in the study, 36% (26) required change in treatment modality. The mean age and body mass index were 44.48 years (SD 15.11, range 18.9 to 73.24 [group A vs group B, 46.82 vs 41.17 years, P = .16] and 29.83 (SD 7.99, range 18.9 to 56 29 [group A vs group B, 58 vs 30.29, P = .72]), respectively. Overall, 65% were women, with no significant gender differences between the groups (group A vs group B = 68% vs 58%, P = .26). While 58% of the population was Caucasian, a significantly higher number of African Americans required change in treatment modality (group A vs group B [24% vs 50%, P = .043]), 61.5% (16) changed from AD to B, of which 44% (7) had their symptoms controlled by a single biologic agent while 56% required more than 1 change in biologic agent. Conclusion: Racial factors may play a role in predicting adequate management of AERD as shown by our study, while the role played by other demographic factors may not be statistically significant. The role of sinonasal and asthma variables in predicting response to therapy is being studied.