A Review of Pharmacologic Neurostimulant Use During Rehabilitation and Recovery After Brain Injury

Abstract

Objective: To describe the efficacy and safety of pharmacologic neurostimulants after neurological injuries such as ischemic or hemorrhagic stroke and traumatic brain injury (TBI), critically evaluate the available literature, and make recommendations regarding which neurostimulants should be considered for use in clinical practice. Data Sources: A literature search of PubMed was performed (1953 to October 2020) to identify relevant articles. Search terms included the following: “neurostimulant, neurorehabilitation” AND “traumatic brain injury, cerebrovascular accident, or stroke.” This review is limited to prospective studies and observational trials. Study Selection and Data Extraction: Relevant English-language studies conducted in humans were considered. Data Synthesis: Cognitive and motor deficits caused by stroke and TBI account for high rates of long-term disability. Although not well-established, pharmacologic agents, broadly characterized as neurostimulants, may be prescribed after brain injury to treat these deficits. When prescribing these medications, it is imperative to be aware of the supporting evidence in order to accurately gauge the risk-benefit profile of each agent. Relevance to Patient Care and Clinical Practice: The following presents a literature review critically evaluating clinical studies that investigate neurostimulant use after brain injury. The intent of this review is to serve as an evidence-based guide for clinicians. Conclusions: The pharmacologic agent with the most supporting literature is amantadine used for cognitive improvement after TBI. Other neurostimulants with positive, despite more limited, evidence include methylphenidate, modafinil, levodopa, and citalopram. Caution is warranted with other neurostimulants given higher rates of adverse effects or lack of benefit observed in clinical trials.