Impact of fluoroquinolone prophylaxis on infectious-related outcomes after hematopoietic cell transplantation

Abstract

Background Patients immediately post-hematopoietic cell transplantation are at high risk for bacteremia. Judicious prophylactic antimicrobial utilization must balance anticipated benefits (reduction infections) versus risk (bacterial resistance, Clostridium difficile). Objective To compare infectious outcomes (primary: incidence bacteremia; secondary: febrile neutropenia, C. difficile, susceptibility of bacteremia, time to discharge and 30-day mortality) between hematopoietic cell transplantation who received fluoroquinolone prophylaxis to those who did not. Methods A local institutional review board-approved retrospective study was conducted on all hematopoietic cell transplantation patients (n\u2009=\u2009171) comparing those who received fluoroquinolone prophylaxis (n\u2009=\u2009105) to those who did not (n\u2009=\u200966). Data included infectious outcomes and mortality for the first 30 days post-hematopoietic cell transplantation. Chi-squared was performed for categorical variables (GraphPad Software Inc., 2015). Secondary analysis compared outcomes within autologous and allogeneic sub-groups. Results Bacteremia was significantly lower for the overall cohort receiving fluoroquinolone (median duration eight days) versus those without fluoroquinolone (15.2% vs. 31.8%; P\u2009<\u20090.01). No difference was seen in C. difficile infection (P\u2009=\u20090.81) or 30-day mortality (2.9% vs. 4.5%; P\u2009=\u20090.67). In the autologous sub-group (n\u2009=\u2009115), bacteremia was significantly lower in the fluoroquinolone cohort (8.5% vs. 27.3%; P\u2009=\u20090.0069), while no differences were seen in C. difficile infection (P\u2009=\u20091) or 30-day mortality (P\u2009=\u20091). In the allogeneic sub-group (n\u2009=\u200956), there was no difference between those with and without fluoroquinolone in bacteremia (29.4% vs. 40.9%; P\u2009=\u20090.4) or C. difficile (P\u2009=\u20090.72); however, there was a trend toward improved 30-day mortality (2.9% vs. 9.1%; P\u2009=\u20090.55). Conclusions Fluoroquinolone prophylaxis reduces incidence of bacteremia in autologous hematopoietic cell transplantation without increasing C. difficile after hematopoietic cell transplantation.