Idiopathic intracranial hypertension and visual function in North Indian population.

Abstract

BACKGROUND\nIdiopathic Intracranial Hypertension (IIH) is a neurological disorder with varied presentation, visual morbidity being the most important one. Literature is sparse as regards the effects of IIH on the visual system in Asians.\n\n\nOBJECTIVE\nAssessment of visual morbidity and change with treatment in IIH patients in North India through a prospective interventional study.\n\n\nMATERIALS AND METHODS\nSixty eyes of newly diagnosed IIH patients were evaluated for functional and structural tests of visual system. Lumbar puncture was performed to establish IIH diagnosis and received oral Carbonic anhydrase inhibitor thereafter. Change in visual function was studied from baseline to 6-month follow-up visit.\n\n\nRESULTS\nMean age of participants at presentation was 33.27\u2009±\u200910.68\u2009years and majority were females (73.3%). Seventy percent eyes (n\u2009=\u200942) had visual acuity 20/20 at presentation. Average Pelli Robson contrast sensitivity (CS) improved from 1.86\u2009±\u20090.34 to 2.11\u2009±\u20090.24 (Friedman Test: X2\u2009=\u200959.2, p\u2009⩽\u20090.001) while number of eyes with detectable visual field deficits reduced from 70% to 43.7%. Retinal nerve fibre layer (RNFL) thickness reduced from 176.27 to 114.97\u2009µ (Friedman Test: X2\u2009=\u200969.3, p\u2009⩽\u20090.001).\n\n\nCONCLUSIONS\nThe socio-demographic profile in our study showed higher male incidence than noted in previous studies. Visual function deficits were present in patients, even in those with 20/20 visual acuity. Significant improvement was seen after lumbar puncture and initiation of medical treatment. CS and RNFL thickness showed significant improvement even after 1\u2009month of treatment and can be used for monitoring IIH patients.