The Massachusetts Hepatitis C Testing Cascade, 2014-2016

Abstract

Objectives: To characterize hepatitis C testing in Massachusetts and guide stakeholders in addressing the needs of people living with hepatitis C. Methods: All persons with a positive laboratory report for anti-hepatitis C virus (HCV) antibody, between 2014 and 2016, were included in the testing cascade. Outcomes were HCV tests received after a positive anti-HCV antibody test: nucleic acid test or genotype test. Logistic regression analyses were performed to determine factors associated with progression through the HCV testing cascade. Results: Among those reported anti-HCV antibody positive, a total of 13\u2009194 (61%) cases had a subsequent RNA-based test, and 79% (10\u2009374/13\u2009194) were confirmed with current, active HCV infection. For confirmed HCV cases, 44% (4557/10\u2009374) had a genotype identified. The median time from an antibody-positive test to a RNA-based test was 29\u2009days (interquartile range [IQR]\u2009=\u20097-151). Differences in moving through the testing cascade were observed by birth cohort and race/ethnicity. Conclusions: Improved surveillance capture of demographic information is needed to help public health agencies ensure equity in HCV diagnosis and linkage to care.