Natural Product Communications | 2019
Pharmacokinetics and Pharmacodynamics of Morroniside: A Review
Abstract
Morroniside belongs to a group of iridoid glycosides and is the primary active component of Cornus officinalis Sieb. et Zucc. This species is a rich source of iridoid glycosides and has been used as a traditional Chinese medicinal herbs for centuries. In this review, we discuss the pharmacokinetics and pharmacodynamics of morroniside. Morroniside is quickly absorbed and metabolized and is widely distributed throughout the body. It also exerts various pharmacological effects. Numerous pharmacological studies have indicated that morroniside plays a role in protecting the nervous system, treating osteoarthritis, inhibiting platelet aggregation, preventing diabetic angiopathies and renal damage, and reducing bone resorption, among others. Future research need to be conducted in support of the development of morroniside as a potential drug.