Multiple Sclerosis Journal - Experimental, Translational and Clinical | 2021
AQP4-IgG autoimmunity in Japan and Germany: Differences in clinical profiles and prognosis in seropositive neuromyelitis optica spectrum disorders
Abstract
Background Clinical outcomes in neuromyelitis optica spectrum disorders (NMOSD) vary across different regions. Objective To describe clinical profiles in Japanese and German NMOSD patients. Methods Medical records of aquaporin-4-immunoglobulin G (AQP4-IgG) positive NMOSD patients from Japan (n\u2009=\u200954) and Germany (n\u2009=\u200938) were retrospectively analyzed. Results The disability status was similar between both cohorts, although Japanese patients had a longer disease duration (13.3\u2009±\u200911.1 vs. 8.1\u2009±\u20096.9\u2009years, p\u2009=\u20090.018) but similar relapse rates. Optic neuritis and myelitis were the most frequent attacks in both cohorts. Brain attacks occurred more frequently in Japanese patients (40.7% vs. 15.8%, p\u2009=\u20090.020). The time from disease onset (median [interquartile range] 2.3 [0.3-10.1] vs. 0.6 [0.2-1.9] years, p\u2009=\u20090.009) and the number of attacks (2.5 [1-7] vs. 2 [1-3], p\u2009=\u20090.047) until start of the first immunotherapy were higher in the Japanese cohort. Rituximab was the most common drug in the German cohort (52.6%) and not given in the Japanese cohort (p\u2009<\u20090.001), where oral prednisolone was the most common drug (92.6% vs. 15.8%, p\u2009<\u20090.001). The frequency of autoimmune comorbidities was higher in the German cohort (39.5% vs. 18.5%, p\u2009=\u20090.047). Conclusion Compared with Japanese NMOSD patients, German patients presented with similar disability despite shorter disease duration and earlier and more frequent immunosuppressive therapy.