Blood | 2019
Roman warfare: targeting of support cells in AML.
Abstract
In this issue of Blood , Edwards et al identified abolishment of colony-stimulating factor 1 (CSF1)–mediated supportive paracrine signaling as a potential novel therapeutic strategy in acute myeloid leukemia (AML). “Famine makes greater havoc in an army than the enemy, and is more terrible than the sword.” This maxim, penned by the Roman writer Vegetius, describes the Roman military principle of depleting enemy resources to increase one’s likelihood of victory. Although this approach was developed for wars involving troops and sieges, Edwards et al have identified a mechanism by which it could be usefully applied to treating AML. 1