Nutrition status and mortality rate during 5-years follow-up in patients with COPD

Abstract

Background: Association between nutrition status and mortality in COPD patients was studied in a limited number of studies. Nutrition status can affect mortality rate. Aim: To assess mortality in COPD patients from the Czech Multicentre Research Database of COPD (CMRD) according to nutrition status. Methods: CMRD of COPD is a multicenter observational real-life prospective study of patients with COPD and post bronchodilator FEV1≤60 %, with enrolled 784 consecutive patients. Patients with assessed Body Mass Index (BMI) and Fat-Free Mass Index (FFMI) at the baseline were included into analysis. Their nutrition status was determined and mortality during 5-years follow-up was evaluated. Results: A total of 343 patients were included into the analysis, 253 men, ex-smokers 73.5 %, mean age 66.6 years, mean FEV1 44.9 %, mean BMI 27.3, average CAT 16.8. There were 18.9 % patients with poor nutrition (incl.cachexia and underweight), 18.1 % normal, 32.1 % overweight and 30.9 % obese patients. Hazard ratio of death HR (95% CI) was 2.398 (1.20-4.778) for patients with underweight, 0.514 (0.288-0.918) for patients with overweight and and 0.682 (0.392-1.188) for obese patients, compared to patients with normal BMI and FFMI (p Conclusion: Nutrition status can be used as a marker for prediction of mortality in COPD patients. The highest mortality in 5-years follow-up was in underweight patient and the lowest in overweight group. Using of combined FFMI and BMI assessment improved prediction of mortality in COPD in comparison to using BMI only.