The impact of decreased 6MWT and exercise-induced desaturation on long-term survival and mortality related to Czech and Spanish phenotypes in patients with severe COPD

Abstract

Introduction: The aim of the study was to assess the impact of decreased 6MWT and exercise-induced desaturation (EID) on long-term survival and mortality related to Czech and Spanish phenotypes in patients with severe COPD. Methods: CMRD is a prospective, observational and multicentre study focussing on the collection and analysis of data on real mortality and morbidity in an unselected population of COPD. Results: A total of 598 patients with performed 6MWT were analysed. Overall 5-year mortality was 33.8% (202 patients). Using the ROC analyses, the statistically significant cut-off value for the 6MWD was 312.5 m (AUC 0.667; p Conclusion: In our cohort, the cachexy phenotype was significantly associated with lower long-term survival in the groups with decreased 6MWT and EID. We believe that identifying the clinical relevant phenotypes within COPD can guide us to a more personalised treatment.