Concentration levels of serum 25-Hydroxyvitamin-D and vitamin D deficiency among children and adolescents of India: a descriptive cross-sectional study

Abstract

Background Vitamin D is an essential micronutrient for the overall health and well-being of individuals. For strong musculoskeletal and neurological development of human body, vitamin D levels during childhood and adolescence have key importance. This is the first national-level study that analyzes the deficiency and concentration of serum 25-Hydroxyvitamin D [25(OH)D)] among Indian children and adolescents with respect to various demographic and socioeconomic characteristics. Methods Data of Comprehensive National Nutrition Survey (CNNS, 2016–18) was utilized for the present study. Vitamin D levels were assessed based on serum 25-hydroxyvitamin D concentration. Prevalence of vitamin D deficiency has been shown for the three age groups: 0–4\u2009years ( n \xa0=\u200912,764), 5–9\u2009years ( n \xa0=\u200913,482), 10–19\u2009years (n\u2009=\u200913,065). Vitamin D deficiency was defined as: serum 25(OH)D\u2009<\u200912\u2009ng/mL; and insufficiency as: 12\u2009ng/ml\xa0≤\xa025(OH)\u2009<\u200920\u2009ng/ml. 25(OH) D level higher than 20\u2009ng/mL was accepted as adequate. Random slope multilevel logistic regression models were employed to assess the demographic and socioeconomic correlates of vitamin D deficiency. Results Mean serum 25(OH)D concentration level was found to be 19.51\u2009±\u20098.76, 17.73\u2009±\u20097.91, and 17.07\u2009±\u20098.16\u2009ng/ml in age group 0–4\u2009years, 5–9\u2009years and 10–19\u2009years respectively. 49.12% of the children aged 0–4\u2009years were having insufficient level of vitamin D. Prevalence of vitamin D deficiency was comparatively higher among female adolescents (76.16%), adolescents living in rural region (67.48), Sikh individuals (0–4\u2009years: 76.28%; 5–9\u2009years: 90.26%; 10–19\u2009years: 89.56%), and adolescents coming from rich households. North-Indian individuals were having substantially higher odds of vitamin D deficiency in all the three age groups. Conclusion The present study demonstrated that the prevalence of vitamin D deficiency is considerably high among children and adolescents of India. The study highlights high-risk group which require prompt policy interventions.