Clinical characteristics of patients with chronic cough in Guangdong, China: a multicenter descriptive study

Abstract

Background The clinical characteristics of patients with chronic cough are reported only in single-center survey in China, being significantly different from that in western countries. Here, we performed a multicenter study to describe the clinical characteristics of chronic cough patients. Methods A cross-sectional observational survey was conducted in thirteen tertiary hospitals of Guangdong, South China. Relevant data were recorded using a standardized questionnaire and analyzed, including demographics, educational attainment, cough features, and concomitant symptoms. Results Of 933 patients in this study, the median age was 40.0 (IQR 31.0–52.0) years with a peaked age of 30–39 years. The proportion of females (487, 52.2\u2009%) was comparable to that of males (446, 47.8\u2009%). Up to 81.9\u2009% of the patients were non-smokers. More than two-thirds of the subjects with chronic cough had a low educational level. The median cough duration was 6.0 (IQR 3.0–24.0) months, and 73.0\u2009% of chronic cough patients presented with dry cough. Laryngeal paresthesia was the most common concomitant symptom (704, 75.5\u2009%), followed by rhinitis/sinusitis-related (350, 37.5\u2009%) and respiratory symptoms (322, 34.5\u2009%). Rhinitis/sinusitis-related symptoms more frequently occurred in patients with productive cough than in those with dry cough (49.0\u2009% vs. 33.0\u2009%, P \u2009<\u20090.001). Moreover, female patients displayed an older age and a higher prevalence of nocturnal cough compared to male patients (both P \u2009<\u20090.05). Conclusions Our results show an equal gender, young profile and laryngeal paresthesia in patients with chronic cough, and different clinical features between females and males.