Executive functioning and neurodevelopmental disorders in early childhood: a prospective population-based study

Abstract

BackgroundExecutive functioning deficits are common in children with neurodevelopmental disorders. However, prior research mainly focused on clinical populations employing cross-sectional designs, impeding conclusions on temporal neurodevelopmental pathways. Here, we examined the prospective association of executive functioning with subsequent autism spectrum disorder (ASD) traits and attention-deficit/hyperactivity disorder (ADHD) traits.MethodsThis study included young children from the Generation R Study, a general population birth cohort. The Brief Rating Inventory of Executive Function-Preschool Version was used to assess parent-reported behavioral executive functioning when the children were 4\xa0years old. ASD traits were assessed at age 6 (n\u2009=\u20093938) using the parent-reported Social Responsiveness Scale. The Teacher Report Form was used to assess ADHD traits at age 7 (n\u2009=\u20092749). Children with high scores were screened to determine possible clinical ASD or ADHD diagnoses. We were able to confirm an ASD diagnosis for n\u2009=\u200956 children by retrieving their medical records and established an ADHD diagnosis for n\u2009=\u2009194 children using the Diagnostic Interview Schedule for Children-Young Child version (DISC-YC). Data were analyzed using hierarchical linear and logistic regressions.ResultsImpaired executive functioning was associated with more ASD and ADHD traits across informants (for ASD traits and diagnoses: β\u2009=\u20090.33, 95% CI [0.30–0.37]; OR\u2009=\u20092.69, 95% CI [1.92–3.77], respectively; for ADHD traits and diagnoses: β\u2009=\u20090.12, 95% CI [0.07–0.16]; OR\u2009=\u20092.32, 95% CI [1.89–2.85], respectively). Deficits in all subdomains were associated with higher levels of ASD traits, whereas only impaired inhibition, working memory, and planning/organization were associated with more ADHD traits.ConclusionsThe findings of the current study suggest a graded association of executive functioning difficulties along the continuum of ASD and ADHD and that problems in executive functioning may be a precursor of ASD and ADHD traits from an early age onwards.