Breast cancer involvement of the nipple-areola complex and implications for nipple-sparing mastectomies: a retrospective observational study in 137 patients

Abstract

IntroductionNipple-sparing mastectomy (NSM) has gained much attention by enhancing the aesthetic outcome in breast carcinoma patients. The aim of this study was to assess the prevalence of malignant affection of the nipple-areola complex (NAC) in breast carcinoma patients and its correlation with prognostic factors for breast cancer.Patients and methodsThis study included 137 female patients diagnosed with breast carcinoma at different disease stages who were admitted to our surgical oncology unit at Suez Canal University Hospital from June 15, 2014 to January 25, 2017. We excluded patients with evidence of nipple involvement as ulceration or patients with previous breast surgery with periareolar incisions. This study was designed to test the hypothesis that the NAC can be spared in certain selected patients. All studied participants provided a full history and underwent general and local clinical examinations, pre-operative laboratory tests, and radiological and pathological evaluations.ResultsThe mean age of the study population was 47.39\u2009±\u20098.01\u2009years. Among the patients, the NAC was affected in 12 (11.40%) patients. Patients with NAC involvement showed a significantly larger tumor size of more than 4\u2009cm and a shorter tumor-nipple distance of less than 2\u2009cm (p\u2009=\u20090.000). Lymph node metastasis was associated with NAC involvement (p\u2009=\u20090.001), with increased risk when more than 10 lymph nodes were involved (p\u2009=\u20090.007). Lymphovascular invasion was a significant predictor of NAC involvement (p\u2009=\u20090.014). Multifocal as well as multicentric tumors were significantly associated with NAC involvement (p\u2009=\u20090.016 and 0.003, respectively). NAC involvement was more likely in Estrogen receptor (ER) and Progesterone receptor (PR) patients than in ER+ and PR+ patients (p\u2009=\u20090.000), while Human epidermal receptor (HER+) patients were more likely to have NAC involvement than HER patients (p\u2009=\u20090.000). Additionally, stage ΙΙΙ cancer was significantly associated with NAC involvement (p\u2009=\u20090.041), and histological grade III disease carried a greater risk than grade I disease of NAC involvement (p\u2009=\u20090.008).ConclusionThe incidence of NAC affection among breast carcinoma patients who underwent mastectomy and axillary clearance was associated with important parameters, such as tumor size, areola edge-tumor distance, lymph node affection, hormonal receptor status and lymphovascular invasion. Accordingly, NAC-preserving surgeries could be tailored to patients with favourable tumor characteristics.