Infectious Diseases of Poverty | 2021
Tocilizumab treatment for COVID-19 patients: a systematic review and meta-analysis
Abstract
Background Coronavirus disease 2019 (COVID-19) has killed over 2.5 million people worldwide, but effective care and therapy have yet to be discovered. We conducted this analysis to better understand tocilizumab treatment for COVID-19 patients. Main text We searched major databases for manuscripts reporting the effects of tocilizumab on COVID-19 patients. A total of 25 publications were analyzed with Revman 5.3 and R for the meta-analysis. Significant better clinical outcomes were found in the tocilizumab treatment group when compared to the standard care group [odds ratio\xa0( OR ) =\u20090.70, 95% confidential interval ( C ): 0.54–0.90, P \u2009=\u20090.007]. Tocilizumab treatment showed a stronger correlation with good prognosis among COVID-19 patients that needed mechanical ventilation ( OR \u2009=\u20090.59, 95% CI , 0.37–0.93, P \u2009=\u20090.02). Among stratified analyses, reduction of overall mortality correlates with tocilizumab treatment in patients less than 65\xa0years old ( OR \u2009=\u20090.68, 95% CI : 0.60–0.77, P \u2009<\u20090.00001), and with intensive care unit patients ( OR \u2009=\u20090.62, 95% CI : 0.55–0.70, P \u2009<\u20090.00001). Pooled estimates of hazard ratio showed that tocilizumab treatment predicts better overall survival in COVID-19 patients ( HR \u2009=\u20090.45, 95% CI : 0.24–0.84, P \u2009=\u20090.01), especially in severe cases ( HR \u2009=\u20090.58, 95% CI 0.49–0.68, P \u2009<\u20090.00001). Conclusions Our study shows that tocilizumab treatment is associated with a lower risk of mortality and mechanical ventilation requirement among COVID-19 patients. Tocilizumab may have substantial effectiveness in reducing mortality among COVID-19 patients, especially among critical cases. This systematic review provides an up-to-date evidence of potential therapeutic role of tocilizumab in COVID-19 management. Graphical abstract